![Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0074774217301393-f03-01-9780128124734.jpg)
Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction - ScienceDirect
![The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/949a9b01-3f7c-4aa7-bc00-2e80cd815320/jnc14612-fig-0005-m.jpg)
The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library
![Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/338/1/92/F9.large.jpg)
Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics
![The G protein-first activation mechanism of opioid receptors by Gi protein and agonists | QRB Discovery | Cambridge Core The G protein-first activation mechanism of opioid receptors by Gi protein and agonists | QRB Discovery | Cambridge Core](https://static.cambridge.org/content/id/urn%3Acambridge.org%3Aid%3Aarticle%3AS2633289221000077/resource/name/S2633289221000077_figAb.png?pub-status=live)
The G protein-first activation mechanism of opioid receptors by Gi protein and agonists | QRB Discovery | Cambridge Core
![Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0028390820304093-fx1.jpg)
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect
![Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling](https://www.science.org/cms/10.1126/scisignal.aai8441/asset/236282b7-67c8-485b-87f5-2c5e8c53b95c/assets/graphic/9_ra117_f1.jpeg)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling
![Frontiers | Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management Frontiers | Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management](https://www.frontiersin.org/files/MyHome%20Article%20Library/508023/508023_Thumb_400.jpg)
Frontiers | Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management
![Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00535-013-0753-x/MediaObjects/535_2013_753_Fig2_HTML.gif)
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Study targets kappa opioid receptor to develop more effective drugs for pain management | Anesthesiology | Washington University School of Medicine in St. Louis Study targets kappa opioid receptor to develop more effective drugs for pain management | Anesthesiology | Washington University School of Medicine in St. Louis](https://anesthesiology.wustl.edu/wp-content/uploads/2023/03/Tao-Che.jpg)
Study targets kappa opioid receptor to develop more effective drugs for pain management | Anesthesiology | Washington University School of Medicine in St. Louis
![IJMS | Free Full-Text | κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance IJMS | Free Full-Text | κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance](https://pub.mdpi-res.com/ijms/ijms-22-01515/article_deploy/html/images/ijms-22-01515-g005.png?1612372727)
IJMS | Free Full-Text | κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance
![Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress | eLife Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress | eLife](https://iiif.elifesciences.org/lax/23785%2Felife-23785-fig7-v1.tif/full/,1500/0/default.jpg)